Formulation and Optimization of Sustained Release Tablets of Diclofenac Sodium Using Guar Gum as Release Modifier

PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ratios viz. 1:1, 1:1.5, 1:2, 1:2.5, 1:3, and 1:3.5 for guar gum. Guar gum was used as matrix forming material, while microcrystalline cellulose as filler to maintain the tablet weight. The tablets were analyzed to determine their hardness, friability, weight variation, and an In-vitro release of drug was performed in phosphate buffer saline pH 7.4 for twenty four hours. Swelling study was also carried out to study dispersibility of gums at different concentrations. RESULTS: All the physical characters of fabricated tablets were within acceptable limits. Results show that as the concentration of gum increases, swelling index also increased proportionally. Batch G6 shows maximum drug release with sustained rate. CONCLUSIONS: It is clear through the dissolution studies that the release profile of Diclofenac sodium from matrix tablets prepared using guar gum was retarded approximately 24 h. Thus guar gum stands as a good candidate for sustained release formulation.